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Glimpazin-L 10

Empagliflozin 10 mg + Linagliptin 5 mg Tablets

Packing: 10 x 10 Tablets
MRP: Rs. 675/- per strip of 10 Tablets
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Glimpazin-L 10 (Empagliflozin 10 mg + Linagliptin 5 mg Tablets):

Product Information

โ€“ Brand Name: Glimpazin-L 10
โ€“ Active Ingredients:
โ€“ Empagliflozin 10 mg
โ€“ Linagliptin 5 mg
โ€“ Form: Tablets

Therapeutic Class

โ€“ Antidiabetic agent (combination)
โ€“ SGLT2 inhibitor + DPP-4 inhibitor

Indications

โ€“ Treatment of type 2 diabetes mellitus
โ€“ Improves glycemic control
โ€“ Reduces risk of cardiovascular events

Dosage and Administration

โ€“ Adult dose: 1 tablet once daily, in the morning
โ€“ Take with or without food

Mechanism of Action

โ€“ Empagliflozin:
โ€“ Inhibits sodium-glucose cotransporter 2 (SGLT2)
โ€“ Reduces glucose reabsorption in kidneys
โ€“ Increases glucose excretion in urine
โ€“ Linagliptin:
โ€“ Inhibits dipeptidyl peptidase-4 (DPP-4)
โ€“ Increases incretin hormone levels
โ€“ Enhances insulin secretion and reduces glucagon levels

Benefits

โ€“ Effective glycemic control
โ€“ Reduced risk of cardiovascular events
โ€“ Convenient once-daily dosing
โ€“ Combination therapy for improved efficacy

Side Effects

โ€“ Common:
โ€“ Hypoglycemia (low blood sugar)
โ€“ Urinary tract infections
โ€“ Increased urination
โ€“ Thirst
โ€“ Headache
โ€“ Less common:
โ€“ Allergic reactions
โ€“ Increased risk of genital mycotic infections
โ€“ Increased risk of acute kidney injury

Contraindications

โ€“ Hypersensitivity to empagliflozin or linagliptin
โ€“ Severe kidney impairment (eGFR <30 mL/min/1.73 mยฒ)
โ€“ End-stage renal disease (ESRD)
โ€“ Dialysis
โ€“ Pregnancy and lactation (caution advised)

Precautions

โ€“ Monitor blood sugar, kidney function, and liver enzymes regularly
โ€“ Inform doctor about concomitant medications
โ€“ Caution in patients with:
โ€“ Renal or hepatic impairment
โ€“ History of pancreatitis
โ€“ History of hypersensitivity reactions