Clamoxitin-625 is a broad-spectrum antibiotic medication containing a combination of:
– Amoxycillin (500 mg): A penicillin-type antibiotic
– Potassium Clavulanate (125 mg): A beta-lactamase inhibitor
Therapeutic Uses
Clamoxitin-625 is indicated for the treatment of:
1. Respiratory tract infections (RTIs)
2. Urinary tract infections (UTIs)
3. Skin and soft tissue infections
4. Otitis media (middle ear infections)
5. Sinusitis
6. Tonsillitis
7. Pharyngitis
Mechanism of Action
Amoxycillin:
1. Interferes with bacterial cell wall synthesis
2. Inhibits bacterial growth and multiplication
Potassium Clavulanate:
1. Inhibits beta-lactamase enzymes produced by bacteria
2. Protects amoxycillin from degradation
Pharmacokinetics
1. Rapid absorption
2. Peak plasma concentrations within 1-2 hours
3. Half-life: 1-1.5 hours
Dosage and Administration
1. Adults: 1 tablet (625 mg) every 12 hours
2. Children: 25-50 mg/kg/day divided every 12 hours
3. Duration: 7-14 days
Contraindications
1. Hypersensitivity to penicillins or cephalosporins
2. Severe liver disease
3. Pregnancy or breastfeeding (caution advised)
Side Effects
Common:
1. Diarrhea
2. Nausea
3. Vomiting
4. Abdominal pain
5. Rash
Serious:
1. Anaphylaxis
2. Stevens-Johnson syndrome
3. Toxic epidermal necrolysis
4. Hepatic dysfunction
Interactions
1. Probenecid (increases amoxycillin levels)
2. Warfarin (increases INR)
3. Methotrexate (increases toxicity)
Precautions
1. Monitor for signs of allergy or intolerance
2. Regularly check liver function tests
3. Use caution in patients with renal impairment
Storage
1. Store at room temperature (20-30°C)
2. Protect from moisture and light
